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5 Discussion and future directions The prevailing view that IF is cardioprotective largely stems from experimental rodent models and intervention studies ( A major goal for future research will be to identify dietary interventions that both optimally support patients with obesity during pharmacotherapy and maintain the metabolic and cardiovascular benefits achieved during treatment

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Stroke 54(12):31733181 Alves-Lopes R, Montezano AC, Neves KB, Harvey A, Rios FJ, Skiba DS et al (2021) Selective inhibition of the C-domain of ACE (angiotensin-converting enzyme) combined with inhibition of NEP (Neprilysin): a potential new therapy for hypertension